skintervene Cellular Renewal Serum with Methylene Blue — 40ml
Advanced Mitochondrial Skincare · Made in the UK

Cellular
Renewal
Serum

with Methylene Blue · 40 ml

An antioxidant-rich gel-serum engineered at the cellular level. Powered by Methylene Blue to support mitochondrial function, skin renewal, and barrier resilience — formulated for skin that performs, not just survives.

£44.99 / 40 ml
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UKManufactured
Cruelty Free
Phenothiazine · C₁₆H₁₈ClN₃S · Methylene Blue

Methylene Blue.
The cellular
energy molecule.

First synthesised in 1876 and now at the frontier of longevity science, Methylene Blue is a redox-active compound capable of cycling between oxidised and reduced states — functioning as a mitochondrial electron carrier to support cellular energy production.

In skin, mitochondrial function declines with age, reducing the cell's capacity for renewal, repair, and resilience. Methylene Blue addresses this at the source — not masking the signs of ageing, but intervening in the process that drives it.

1876Year of first synthesis — over a century of scientific study
~5×Antioxidant capacity vs. conventional topical antioxidants in vitro
ATPSupports mitochondrial electron transport, the engine of cellular energy
40mlPrecision-dosed at therapeutic concentration — not a token inclusion

Nine actives.
One precise purpose.

01
Hero
Methylene Blue
Methylene Blue

A redox-active phenothiazine compound that supports mitochondrial electron transport, antioxidant defence, and cellular energy. The cornerstone of this formula.

02
Niacinamide
Niacinamide

Vitamin B3 that visibly minimises pores, regulates sebum, strengthens the skin barrier, and supports an even skin tone. One of the most evidence-backed actives in skincare.

03
Rare
Tremella Mushroom
Tremella Fuciformis Sporocarp Extract

The "beauty mushroom" of Traditional Asian medicine. Forms a moisture-binding film with hyaluronic acid-like hydration properties.

04
Ectoin
Ectoin

A natural extremolyte produced by bacteria in harsh environments. Forms a hydration shell around proteins and cells, protecting against UV, pollution, and environmental stressors.

05
N-Acetyl Glucosamine
N-Acetyl Glucosamine

Supports hyaluronic acid synthesis, helps suppress excess melanin production, and promotes cell turnover for refined texture and tone.

06
Centella Asiatica
Centella Asiatica Extract

Proven collagen-stimulating and wound-healing properties. Soothes inflammation, supports barrier function, and promotes skin resilience.

07
Green Tea Extract
Camellia Sinensis Leaf Extract

Rich in EGCG polyphenols — one of nature's most potent antioxidants. Protects against UV-induced oxidative damage and supports skin clarity.

08
Beta-Glucan
Beta-Glucan

Clinically demonstrated ability to penetrate the epidermis, stimulate collagen synthesis, and accelerate wound healing.

09
Squalane + Panthenol
Squalane · Panthenol

Lipid-identical emollient and pro-vitamin B5. Locks in moisture, restores softness, and accelerates barrier recovery without pore occlusion.

The daily
intervention.

I
Cleanse

Begin with a gentle cleanser. Pat skin dry — do not rub. The formula performs optimally on clean, receptive skin.

II
Apply

Dispense 1–2 pumps. Press gently into skin using fingertips — do not drag. Focus on areas of concern.

III
Absorb

Allow 60 seconds for the gel-serum texture to fully absorb before layering additional products.

IV
Protect

Follow with moisturiser and SPF 50+ in the morning. Use morning or evening — or both, for accelerated results.

Efficacy over
aesthetics.

Every ingredient in this formula earns its place. There are no fillers, no fragrance, no empty volume. The concentration of each active is set to the threshold where clinical evidence begins — not to the minimum required for marketing.

Methylene Blue has been the subject of increasing scientific attention for its mitochondria-supportive properties. We include it not as a trend ingredient, but because the evidence for its role in cellular antioxidant defence is compelling — and growing.

The base is a lightweight, fast-absorbing gel that delivers actives efficiently without greasiness or occlusion. Suitable for all skin types, including oily and acne-prone.

Volume40 ml / 1.35 fl oz
PAO6M after opening
Batch No.RB2064MB
OriginMade in the UK
ManufacturerSkintervene UK, London SW19 3TL
Skin TypeAll skin types
VeganYes
FragranceFragrance-free

Aqua (Water), Glycerin, Niacinamide, Squalane, Caprylic/Capric Triglyceride, N-Acetyl Glucosamine, Panthenol, Tremella Fuciformis Sporocarp Extract, Centella Asiatica Extract, Camellia Sinensis Leaf Extract, Beta-Glucan, Ectoin, Allantoin, Arginine, Serine, Glycine, Hydroxyethylcellulose, Cetearyl Alcohol, Cetearyl Glucoside, Xanthan Gum, Sodium Phytate, Methylene Blue, Citric Acid, Phenoxyethanol, Ethylhexylglycerin

Caution

For external use only. Avoid contact with eyes. Discontinue use if irritation occurs. Store in a cool, dry place out of direct sunlight. Keep out of reach of children.

Answered with
precision.

What is Methylene Blue and why is it in a skincare serum?
+

Methylene Blue is a synthetic compound with over 140 years of scientific history. At the topical level it functions as a redox-active antioxidant — acting as a mitochondrial electron carrier that may support the cellular energy processes declining with skin ageing.

Will Methylene Blue stain my skin blue?
+

No. At the concentration used in our formula, Methylene Blue is effectively colourless once incorporated into the gel base. It will not stain skin, fabrics, or bedding. The serum has a very faint blue-green tint in the bottle which disappears on application.

Is this suitable for sensitive or reactive skin?
+

Yes. Ectoin, Centella Asiatica, and Allantoin provide soothing, barrier-supportive benefits. The formula is completely fragrance-free with no known sensitisers — suitable for all skin types including reactive skin.

Can I layer this with Vitamin C, retinol, or acids?
+

Generally yes. Apply before Vitamin C as Methylene Blue is pH-sensitive. With retinol, alternate morning/evening or apply this serum first and allow it to fully absorb. Avoid combining with high-strength AHA/BHA in the same application.

How long before I see results?
+

Hydration benefits from Tremella, Glycerin, and Ectoin are typically visible within 24–48 hours. Structural improvements — texture, barrier resilience, and tone evenness — at 4–6 weeks. Methylene Blue's mitochondrial effects are best assessed over 90 days of consistent use.

Where is this made and how is it tested?
+

Manufactured in London SW19. Dermatologist-reviewed, patch-tested, and produced in full compliance with UK Cosmetics Regulations. We operate a transparent supply chain with complete batch traceability.

Cellular Renewal Serum
with Methylene Blue · 40 ml
£44.99